Catherine was the daughter of Richard Woodville, 1st Earl Rivers and Jacquetta of Luxembourg. The Woodville family became important when Elizabeth Woodville, Catherine's elder sister married Edward IV, King of England. Catherine was married twice. Her first marriage was to Henry Stafford, Duke of Buckingham and was arranged when they were both children. It may have been that Stafford resented the marriage because Catherine was not of noble birth, but together thay had four of five children. When Stafford led an unsuccessful rebellion in the name of Henry Tudor he was executed for treason. Catherine's second marriage was to Jasper Tudor, the uncle of King Henry VII of England. This was arranged after Richard III was defeated at the battle of Bosworth.

 Woodville, Catherine (b.1458? - d.1497?)
    +Stafford, Henry (Duke of Buckingham) (b.1455 - ex.1483)
    +Tudor, Jasper (Earl of Pembroke) (b.1431? - d.1496)